Sign in →

Order Name CARTF Carbamazepine Profile, Serum

Important Note

*This test is orderable in Cerner as Carbamazepine Profile, S MAYO

Useful For

Monitoring patients exhibiting symptoms of carbamazepine toxicity whose total serum carbamazepine concentration is within the therapeutic range, but who may be producing significant levels of the active metabolite epoxide

 

Free carbamazepine concentration may also be useful to monitor in patients with altered or unpredictable protein binding capacity

Profile Information

Test ID Reporting Name Available Separately Always Performed
CARTA Carbamazepine, Tot, S Yes Yes
1011E Carb-10,11-Epoxide, S No Yes
CARF Carbamazepine, Free, S Yes Yes

Method Name

CARTA: Homogeneous Microparticle Agglutination Immunoassay

1011E: High-Performance Liquid Chromatography (HPLC)

CARF: Ultrafiltration Followed by Homogeneous Microparticle Agglutination Immunoassay

Reporting Name

Carbamazepine Profile, S

Specimen Type

Serum Red


Specimen Required


Container/Tube: Red top

Specimen Volume: 2 mL

Submission Container/Tube: Plastic vial

Collection Instructions:

1. Draw blood 12 hours (trough value) after last dose.

2. Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 7 days
  Frozen  28 days
  Ambient  48 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

CARBAMAZEPINE, TOTAL

Therapeutic: 4.0-12.0 mcg/mL

Critical value: ≥15.0 mcg/mL

 

CARBAMAZEPINE-10,11-EPOXIDE

Therapeutic: 0.4-4.0 mcg/mL

Toxic concentration: ≥8.0 mcg/mL

 

CARBAMAZEPINE, FREE

Therapeutic: 1.0-3.0 mcg/mL

Critical value: ≥4.0 mcg/mL

Day(s) Performed

CARTA, CARF: Monday through Sunday

1011E: Tuesday

Report Available

Same day/1 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80156-Carbamazepine, total

80157-Carbamazepine, free

80161-Carbamazepine-10,11-Epoxide

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CARTF Carbamazepine Profile, S 50337-5

 

Result ID Test Result Name Result LOINC Value
CARF Carbamazepine, Free, S 3433-0
7467 Carb-10,11-Epoxide, S 9415-1
CARTA Carbamazepine, Tot, S 3432-2

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.